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Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma.
Yi L, Zhang S, Feng Y, Wu W, Chang C, Chen D, Chen S, Zhao J, Zhen G. Yi L, et al. Clin Exp Allergy. 2021 Dec;51(12):1566-1576. doi: 10.1111/cea.13961. Epub 2021 Jun 19. Clin Exp Allergy. 2021. PMID: 34075657
Epithelial galectin-13 mRNA levels in asthmatic subjects were strongly correlated with eosinophilic airway inflammation (the percentage of sputum eosinophils, the number of eosinophils in bronchial submucosa and FeNO) and the expression of Th2 signature genes (CLCA1, POSTN and …
Epithelial galectin-13 mRNA levels in asthmatic subjects were strongly correlated with eosinophilic airway inflammation (the percentage of s …
MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy: in vitro and ex vivo evidence.
Elhadad S, Redmond D, Huang J, Tan A, Laurence J. Elhadad S, et al. Clin Exp Immunol. 2023 Jul 21;213(2):252-264. doi: 10.1093/cei/uxad055. Clin Exp Immunol. 2023. PMID: 37191586
The top 40 narsoplimab-affected transcripts included upregulation of SerpinB2, which blocks apoptosis by inactivating procaspase 3; CHAC1, which inhibits apoptosis in association with mitigation of oxidative stress responses; and pro-angiogenesis proteins TM4SF18, ASPM, an …
The top 40 narsoplimab-affected transcripts included upregulation of SerpinB2, which blocks apoptosis by inactivating procaspase 3; C …
Elevated CXCL14 in Induced Sputum Was Associated with Eosinophilic Inflammation and Airway Obstruction in Patients with Asthma.
Du L, Xu C, Shi J, Tang L, Xiao L, Lei C, Liu H, Liang Y, Guo Y, Tang K. Du L, et al. Int Arch Allergy Immunol. 2022;183(11):1216-1225. doi: 10.1159/000526367. Epub 2022 Sep 5. Int Arch Allergy Immunol. 2022. PMID: 36063806
Besides, the correlations between CXCL14 and eosinophilic inflammation indicators (FeNO, EOS#, and IgE), Th2 signature genes (SERPINB2, POSTN, and CLCA1), inflammatory cytokines (IL-4, IL-5, IL-10, IL-13, IL-25, IL-33, TSLP, IL-8, IL-17A, IFN-gamma, and IL-2), and airway o …
Besides, the correlations between CXCL14 and eosinophilic inflammation indicators (FeNO, EOS#, and IgE), Th2 signature genes (SERPINB2 …
Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation.
Mo Y, Zhang K, Feng Y, Yi L, Liang Y, Wu W, Zhao J, Zhang Z, Xu Y, Hu Q, He J, Zhen G. Mo Y, et al. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L245-L254. doi: 10.1152/ajplung.00362.2017. Epub 2018 Nov 1. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30382768 Free article.
Moreover, epithelial SERPINB10 expression was strongly correlated with the epithelial gene signature ( CLCA1, POSTN, and SERPINB2) for type 2 status. In normal human bronchial epithelial cells cultured at air-liquid interface, knockdown of SERPINB10 suppressed IL-13-stimul …
Moreover, epithelial SERPINB10 expression was strongly correlated with the epithelial gene signature ( CLCA1, POSTN, and SERPINB2) fo …
Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia.
Glass C, Wuertzer C, Cui X, Bi Y, Davuluri R, Xiao YY, Wilson M, Owens K, Zhang Y, Perkins A. Glass C, et al. PLoS One. 2013 Jun 27;8(6):e67134. doi: 10.1371/journal.pone.0067134. Print 2013. PLoS One. 2013. PMID: 23826213 Free PMC article.
Specifically, we identified EVI1 directly binds to and downregulates the master myeloid differentiation gene Cebpe and several of its downstream gene targets critical for terminal myeloid differentiation. We also found EVI1 binds to and downregulates Serpinb2 as well as nu …
Specifically, we identified EVI1 directly binds to and downregulates the master myeloid differentiation gene Cebpe and several of its downst …
Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma.
Johnson DC, Corthals SL, Walker BA, Ross FM, Gregory WM, Dickens NJ, Lokhorst HM, Goldschmidt H, Davies FE, Durie BG, Van Ness B, Child JA, Sonneveld P, Morgan GJ. Johnson DC, et al. J Clin Oncol. 2011 Mar 1;29(7):797-804. doi: 10.1200/JCO.2010.28.0792. Epub 2011 Jan 18. J Clin Oncol. 2011. PMID: 21245421
RESULTS: We report TrPN associations with SNPs-ABCA1 (rs363717), ICAM1 (rs1799969), PPARD (rs2076169), SERPINB2 (rs6103), and SLC12A6 (rs7164902)-where we show cross validation of the associations in both trials. ...
RESULTS: We report TrPN associations with SNPs-ABCA1 (rs363717), ICAM1 (rs1799969), PPARD (rs2076169), SERPINB2 (rs6103), and SLC12A6 …
Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198/FGFR1 fusion kinase that is involved in atypical myeloproliferative disease.
Kasyapa CS, Kunapuli P, Hawthorn L, Cowell JK. Kasyapa CS, et al. Blood. 2006 May 1;107(9):3693-9. doi: 10.1182/blood-2005-04-1505. Epub 2006 Jan 12. Blood. 2006. PMID: 16410451 Free PMC article.
Expression of the plasminogen activator inhibitor-2 (PAI-2/SERPINB2) was highly increased in cells expressing the fusion gene. ...
Expression of the plasminogen activator inhibitor-2 (PAI-2/SERPINB2) was highly increased in cells expressing the fusion gene. ...
Transcriptosome and serum cytokine profiling of an atypical case of myelodysplastic syndrome with progression to acute myelogenous leukemia.
Mahadevan D, DiMento J, Croce KD, Riley C, George B, Fuchs D, Mathews T, Wilson C, Lobell M. Mahadevan D, et al. Am J Hematol. 2006 Oct;81(10):779-86. doi: 10.1002/ajh.20690. Am J Hematol. 2006. PMID: 16838325 Free article.
GEP demonstrated a unique "tumor molecular profile," which included overexpression of oncogenes (HOXA9, N-MYC, KOC1), proliferative genes (PAWR, DLG5, AKR1C3), invasion/metastatic genes (FN1, N-CAM-1, ITGB5), pro-angiogenesis genes (c-Kit), and down regulation of tumor suppressor …
GEP demonstrated a unique "tumor molecular profile," which included overexpression of oncogenes (HOXA9, N-MYC, KOC1), proliferative genes (P …